Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases

Curr Opin Genet Dev. 2004 Apr;14(2):113-9. doi: 10.1016/j.gde.2004.02.002.


Replication of damaged DNA often requires a DNA polymerase in addition to the cell's normal replicase. Recent research has begun to shed light on the switch from a high-fidelity replicative polymerase to a low-fidelity translesion polymerase that occurs at a stalled replication fork. A picture is emerging in which eukaryotic replicative clamps are posttranslationally modified by ubiquitination, SUMOylation or phosphorylation. It is believed that such modifications help to regulate the access of translesion polymerases to the nascent primer terminus.

Publication types

  • Review

MeSH terms

  • DNA Damage*
  • DNA Repair / physiology*
  • DNA Replication / physiology*
  • DNA-Directed DNA Polymerase / physiology*
  • SUMO-1 Protein / physiology
  • Schizosaccharomyces / enzymology
  • Schizosaccharomyces / genetics
  • Ubiquitin / physiology


  • SUMO-1 Protein
  • Ubiquitin
  • DNA replicase
  • DNA-Directed DNA Polymerase