The highly conserved and multifunctional NuA4 HAT complex

Curr Opin Genet Dev. 2004 Apr;14(2):147-54. doi: 10.1016/j.gde.2004.02.009.


Histone acetyltransferase complexes have been shown to be key regulators of gene expression. Among these, the NuA4 complex, first characterized in yeast, stands out as it controls multiple key nuclear functions in eukaryotic cells. Many subunits of this protein assembly have been directly linked to global and targeted acetylation of histone H4 tails in vivo, regulation of transcription, cell-cycle progression as well as to the process of DNA repair. Recent studies presented here have established its remarkable structural conservation from yeast to human cells and contributed to the understanding of its diverse functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyltransferases / physiology*
  • DNA Repair / physiology
  • Histone Acetyltransferases
  • Humans
  • Lysine Acetyltransferase 5
  • Multienzyme Complexes / physiology*
  • Saccharomyces cerevisiae / enzymology
  • Transcription, Genetic / physiology


  • Multienzyme Complexes
  • Acetyltransferases
  • Histone Acetyltransferases
  • KAT5 protein, human
  • Lysine Acetyltransferase 5