Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?

Curr Opin Genet Dev. 2004 Apr;14(2):165-73. doi: 10.1016/j.gde.2004.01.007.

Abstract

ATP-dependent chromatin remodelling enzymes act to alter chromatin structure during gene regulation. Studies of the ATPase motors that drive these enzymes support the notion that they function as ATP-dependent DNA translocases with limited processivity. The action of these enzymes on nucleosomes results in the alteration of nucleosome positioning and structure. Recent studies have shown that ATP-dependent chromatin remodelling can also either remove or exchange histone dimers between nucleosomes. This provides a new means by which the incorporation of histone variants can be directed. Additional observations support roles for ATP-dependent remodelling enzymes throughout the transcription cycle.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / physiology*
  • Adenosine Triphosphate / physiology*
  • Animals
  • Chromatin Assembly and Disassembly / physiology*
  • Dimerization
  • Histones / physiology*
  • Humans
  • Nucleosomes / physiology

Substances

  • Histones
  • Nucleosomes
  • Adenosine Triphosphate
  • Adenosine Triphosphatases