At the crossroads of growth control; making ribosomal RNA

Curr Opin Genet Dev. 2004 Apr;14(2):210-7. doi: 10.1016/j.gde.2004.02.005.


Although the mechanisms of cell cycle control are well established, the factors controlling cell growth and target size are still poorly understood. Much evidence suggests that ribosome biogenesis, and in particular the synthesis of the rRNAs, plays a central role not only in permitting growth, but also in regulating it. In the past few years we have begun to penetrate the network linking rRNA gene transcription to growth.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Size / genetics
  • Cell Size / physiology
  • Gene Silencing / physiology
  • Growth / physiology*
  • RNA Polymerase I / physiology
  • RNA Polymerase II / physiology
  • RNA, Ribosomal / physiology*
  • Yeasts / genetics
  • Yeasts / physiology


  • RNA, Ribosomal
  • RNA Polymerase II
  • RNA Polymerase I