Early events in glutamate receptor trafficking

Curr Opin Cell Biol. 2004 Apr;16(2):134-9. doi: 10.1016/j.ceb.2004.01.003.


Glutamate receptors are the primary mediators of excitatory synaptic transmission in the mammalian central nervous system. Activity-dependent changes in the number of postsynaptic glutamate receptors underlie aspects of synaptic plasticity and provide a mechanism for information storage in the brain. Recent work shows that receptor exit from the endoplasmic reticulum represents a critical regulatory step in glutamate receptor trafficking to the neuronal cell surface.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Neuronal Plasticity / physiology
  • Neurons / metabolism*
  • Protein Transport / physiology
  • Receptors, Glutamate / metabolism*
  • Synaptic Membranes / metabolism*
  • Synaptic Transmission / physiology


  • Receptors, Glutamate