Beta-Arrestins: Traffic Cops of Cell Signaling

Curr Opin Cell Biol. 2004 Apr;16(2):162-8. doi: 10.1016/j.ceb.2004.01.001.

Abstract

Once thought to function only in the desensitization of seven membrane spanning receptors (7MSRs), the ubiquitous beta-arrestin molecules are increasingly appreciated to play important roles in the endocytosis and signaling of these receptors. These functions reflect the ability of the beta-arrestins to bind an ever-growing list of signaling and endocytic elements, often in an agonist-dependent fashion. One heavily studied system is that leading to MAP kinase activation via beta-arrestin-mediated scaffolding of these pathways in a receptor-dependent fashion. The beta-arrestins are also found to be involved in the regulation of novel receptor systems, such as Frizzled and TGFbeta receptors.

Publication types

  • Review

MeSH terms

  • Animals
  • Arrestins / metabolism*
  • Endocytosis / physiology
  • Humans
  • MAP Kinase Signaling System / physiology
  • Membrane Proteins / metabolism*
  • Protein Transport / physiology
  • Receptors, Cell Surface / metabolism*
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction / physiology*
  • beta-Arrestins

Substances

  • Arrestins
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • beta-Arrestins
  • seven-transmembrane G-protein-coupled receptor