Partial lesion of thalamic ventral intermediate nucleus after chronic high-frequency stimulation

Jasmine Henderson; Michael Rodriguez; Dudley O'Sullivan; Malcolm Pell; Victor Fung; Alim Louis Benabid; Glenda Halliday

doi:10.1002/mds.10709

Partial lesion of thalamic ventral intermediate nucleus after chronic high-frequency stimulation

Mov Disord. 2004 Jun;19(6):709-11. doi: 10.1002/mds.10709.

Authors

Jasmine Henderson¹, Michael Rodriguez, Dudley O'Sullivan, Malcolm Pell, Victor Fung, Alim Louis Benabid, Glenda Halliday

Affiliation

¹ Department of Pharmacology, University of Sydney, NSW, Australia. henderson@med.usyd.edu.au

PMID: 15197715
DOI: 10.1002/mds.10709

Abstract

A 73-year-old man with Parkinson's disease underwent thalamic stimulation for disabling tremor with excellent results only when stimulation on. Post-mortem neuropathology (7 years postoperatively) revealed 60% cell loss within 0.5 mm of the electrode tip. Tremor improvement was attributable to chronic stimulation, not microthalamotomy.

Publication types

Case Reports

MeSH terms

Electric Stimulation / instrumentation
Humans
Male
Middle Aged
Parkinson Disease / complications
Parkinson Disease / pathology*
Parkinson Disease / therapy*
Radio Waves*
Ventral Thalamic Nuclei / pathology*