Asymptomatic testicular adrenal rest tumours in adolescent and adult males with congenital adrenal hyperplasia: basal and follow-up investigation after 2.6 years

J Pediatr Endocrinol Metab. 2004 Apr;17(4):645-53. doi: 10.1515/jpem.2004.17.4.645.


Aim: To study the course of asymptomatic testicular adrenal rest tumours in patients with congenital adrenal hyperplasia (CAH) and the association between tumour changes and glucocorticoid therapy adjustments.

Patients and methods: Fifteen male patients with CAH (21-hydroxylase deficiency), in whom asymptomatic testicular adrenal rest tumours had been found at a baseline investigation, underwent scrotal ultrasonography and venous blood sampling (for LH, FSH and testosterone) on average 2.6 years later. The level of hormonal control was assessed by measurement of androstenedione in three diurnal saliva samples. Data on changes in glucocorticoid therapy since baseline were obtained from the patients' records.

Results: Tumour decrease, defined as > or =30% decrease in the sum of the longest diameter(s) of the lesion(s), was found in six patients; tumour increase, defined as > or =20% increase, in six and stable tumours in three patients. All three patients with overtreatment showed tumour decrease and of the six patients with undertreatment only one showed tumour decrease. Tumour increase was not only observed in undertreated patients but also in patients with adequate treatment. Changing the night dose of hydrocortisone into dexamethasone, to obtain prolonged ACTH suppression, had resulted in better adrenal suppression in only one patient.

Conclusions: Tumour decrease could be achieved by aiming at adrenal oversuppression, but the required high glucocorticoid doses may induce side effects. In asymptomatic tumours in young male patients with CAH, a practical guideline could be to optimise adrenal suppression to a maximal tolerable glucocorticoid dose and to offer analysis and cryopreservation of semen as soon as the patient can be motivated.

MeSH terms

  • Adolescent
  • Adrenal Hyperplasia, Congenital / complications*
  • Adrenal Hyperplasia, Congenital / drug therapy*
  • Adrenal Rest Tumor / blood
  • Adrenal Rest Tumor / diagnostic imaging
  • Adrenal Rest Tumor / etiology*
  • Adult
  • Androstenedione / antagonists & inhibitors
  • Dexamethasone / administration & dosage*
  • Dexamethasone / therapeutic use
  • Dose-Response Relationship, Drug
  • Follicle Stimulating Hormone / blood
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage*
  • Glucocorticoids / therapeutic use
  • Humans
  • Hydrocortisone / administration & dosage*
  • Hydrocortisone / therapeutic use
  • Luteinizing Hormone / blood
  • Male
  • Saliva / metabolism
  • Testicular Neoplasms / blood
  • Testicular Neoplasms / diagnostic imaging
  • Testicular Neoplasms / etiology*
  • Testosterone / blood
  • Ultrasonography


  • Glucocorticoids
  • Testosterone
  • Androstenedione
  • Dexamethasone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Hydrocortisone