Pathogenesis of perinatal programming

Curr Opin Nephrol Hypertens. 2004 Jul;13(4):459-64. doi: 10.1097/01.mnh.0000133977.09688.2f.


Purpose of review: In recent years, there has been an increase in research designed to delineate the underlying causes of perinatal programming. Starting with epidemiological observations that birth weight was inversely associated with cardiovascular disease, a variety of studies both in humans and in experimental models have begun to demonstrate how the perinatal milieu can subtly alter vasculogenesis and nephrogenesis. Additionally, rates of prenatal and postnatal growth each appear to contribute to future vascular, renal and metabolic function. The purpose of this review is to discuss recent reports that have begun to elucidate factors that initiate perinatal programming as it affects renal disease and cardiovascular disease in later life.

Recent findings: Nephrogenesis per se is affected by changes in maternal nutrition and health, and recent data more specifically linking these changes with renal function and hypertension are presented. Additionally, renal functional changes in later life may be influenced by changes in renal tubular transporters noted early when maternal nutrition is compromised. Various hormonal systems affected by maternal nutrition in utero may effect subsequent changes in renal function via subtle alterations in renal function and structure initiated during nephrogenesis.

Summary: Current research is beginning to clarify certain aspects of perinatal programming and indicates that broad educational programmes might ultimately lessen both perinatal risks and long-term outcomes by encouraging therapeutic interventions in at-risk persons.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / embryology
  • Cardiovascular System / embryology*
  • Cardiovascular System / physiopathology
  • Embryonic and Fetal Development / physiology*
  • Female
  • Gene Expression Regulation, Developmental / physiology
  • Humans
  • Hypothalamo-Hypophyseal System / embryology
  • Kidney / embryology*
  • Kidney / physiopathology
  • Kidney Diseases / embryology
  • Nephrons / embryology
  • Nephrons / physiopathology
  • Pituitary-Adrenal System / embryology
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Rats