Familial hypercholesterolemia in South Africa

Semin Vasc Med. 2004 Feb;4(1):93-5. doi: 10.1055/s-2004-822991.


South Africa, especially the Caucasian part of the population, has one of the highest incidences of familial hypercholesterolemia in the world. The founder effect in this region has led to this high incidence and to a limited number of mutations in the low-density lipoprotein-receptor gene. This chapter describes current situation concerning the management of familial hypercholesterolemia in South Africa.

MeSH terms

  • Humans
  • Hyperlipoproteinemia Type II / epidemiology*
  • Incidence
  • South Africa / epidemiology