Developments in the management and appropriate use of oral anticoagulant therapy have resulted in improved clinical outcomes for patients. Additionally, the results of randomized clinical trials have defined the appropriate indications for oral anticoagulant therapy. These advancements have provided both clinicians and patients with the evidence needed to make informed decisions about the use of anticoagulant therapy. The changes in behavior and lifestyle modifications imposed by oral anticoagulant therapy may affect the quality-of-life of patients. Recent studies have begun to examine issues surrounding oral anticoagulant therapy. As clinicians and patients weigh the evidence of the risks and benefits of oral anticoagulant therapy, they need to implicitly consider quality-of-life issues that may influence their decision-making.