Calcium-sensing receptor regulation of renal mineral ion transport

Cell Calcium. 2004 Mar;35(3):229-37. doi: 10.1016/j.ceca.2003.10.016.


Extracellular calcium has long been known to affect the rate and magnitude of renal calcium and phosphate recovery. In this review, we consider some of these findings in light of our present understanding of the tubular localization of the calcium-sensing receptor (CaSR). Experiments directly implicating the CaSR in regulating calcium and phosphate transport are described. These results point to an important role of the CaSR in regulating PTH-dependent calcium absorption by cortical thick ascending limbs and on PTH-sensitive proximal tubule phosphate transport. Possible avenues for further investigation are suggested.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport / physiology
  • Calcium / metabolism
  • Calcium-Transporting ATPases / metabolism
  • Cation Transport Proteins
  • Gadolinium / metabolism
  • Humans
  • Immunohistochemistry
  • Kidney / chemistry
  • Kidney / physiology*
  • Parathyroid Hormone / metabolism
  • Phosphate Transport Proteins / metabolism
  • Phosphates / metabolism
  • Plasma Membrane Calcium-Transporting ATPases
  • Receptors, Calcium-Sensing / physiology*
  • Water / metabolism


  • Cation Transport Proteins
  • Parathyroid Hormone
  • Phosphate Transport Proteins
  • Phosphates
  • Receptors, Calcium-Sensing
  • Water
  • Gadolinium
  • Plasma Membrane Calcium-Transporting ATPases
  • Calcium-Transporting ATPases
  • Calcium