Pregnancy outcome following preterm premature rupture of the membranes at less than 26 weeks' gestation

Aust N Z J Obstet Gynaecol. 1992 May;32(2):120-4. doi: 10.1111/j.1479-828x.1992.tb01922.x.


The outcome of 71 singleton pregnancies where premature rupture of the membranes (PROM) occurred at gestations of less than 26 weeks was assessed retrospectively. The incidence of chorioamnionitis was 39.4% and the overall maternal morbidity rate was 53% but there were no long-term maternal sequelae. The latent period from PROM until delivery ranged from less than 12 hours to 77 days, with 41% of women delivering within 1 week. There was no increased risk of infection with increasing latent period. The perinatal mortality was 66.2% (26.7% stillbirths and 39.4% neonatal deaths). There was a 65% chance of a live baby if PROM occurred between 24-26 weeks but only 5 of 40 fetuses (12.5%) survived if PROM occurred before 24 weeks. The use of antibiotics, tocolytics and steroids in an uncontrolled manner is reported. Overall there is little serious risk to the mother if a conservative approach is adopted but only about one-third of such women will take home a live baby.

MeSH terms

  • Chorioamnionitis / etiology
  • Female
  • Fetal Membranes, Premature Rupture* / complications
  • Fetal Membranes, Premature Rupture* / therapy
  • Gestational Age
  • Humans
  • Infant Mortality
  • Infant, Newborn
  • Morbidity
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Trimester, Second
  • Retrospective Studies
  • Time Factors