Fine mapping of milk production QTL on BTA6 by combined linkage and linkage disequilibrium analysis

J Dairy Sci. 2004 Mar;87(3):690-8. doi: 10.3168/jds.S0022-0302(04)73212-9.


Combined linkage and linkage disequilibrium analysis were used to refine the position of a previously detected QTL affecting milk production traits on bovine chromosome 6. Through a series of single- and multitrait and single- and multipoint QTL analyses, the QTL could be positioned to a 7.5-cM interval surrounded by the markers BMS2508 and FBN12. The most significant results were found for fat percentage and protein percentage. This effect seemed to be caused by a QTL allele embedded in one specific marker haplotype that caused a reduction in fat and protein yields and a concomitant increase of milk yield, thus resulting in a marked reduction of fat and protein percentages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Cattle / genetics*
  • Chromosome Mapping*
  • Female
  • Genetic Linkage / genetics*
  • Haplotypes
  • Lactation / genetics*
  • Linkage Disequilibrium / genetics*
  • Lipids / analysis
  • Milk / chemistry
  • Milk Proteins / analysis
  • Quantitative Trait Loci / genetics*


  • Lipids
  • Milk Proteins