Long-term warfarin treatment may induce arterial calcification in humans: case report

Clin Invest Med. 2004 Apr;27(2):107-9.


Purpose: To report a case of arterial calcification in a person who has had long-term treatment with warfarin. Although the anticoagulant has been shown to induce arterial calcification in laboratory animals, there have been no previous reports implicating warfarin as a clinical factor.

Clinical features: On routine annual examination, the coronary arteries of a healthy man with no symptoms who has had long-term warfarin treatment were found to be highly calcified.

Conclusion: It would be prudent to further evaluate experimentally the relationship of warfarin and arterial calcification. We suggest that physicians prescribing long-term warfarin treatment consider arterial calcification as one of its potential consequences.

Publication types

  • Case Reports

MeSH terms

  • Anticoagulants / adverse effects*
  • Arteries / drug effects*
  • Arteries / pathology
  • Calcinosis / chemically induced*
  • Humans
  • Male
  • Middle Aged
  • Warfarin / adverse effects*


  • Anticoagulants
  • Warfarin