A new route to aristocularine alkaloids: total synthesis of aristoyagonine

J Org Chem. 2004 Jun 25;69(13):4527-30. doi: 10.1021/jo049869g.

Abstract

A short and efficient synthesis of aristocularines, involving the sequential construction of phosphorylated 4-alkoxyisoindolinones, Horner-type reaction, and ultimate cyclization by diaryl ether coupling, is disclosed. The success of this new conceptual approach is demonstrated by the total synthesis of the aristocularine alkaloid aristoyagonine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Fumariaceae / chemistry*
  • Isoquinolines / chemical synthesis*
  • Molecular Structure

Substances

  • Isoquinolines
  • aristocularine
  • aristoyagonine