Membrane targeting: getting Arl to the Golgi

Curr Biol. 2004 Jun 22;14(12):R483-5. doi: 10.1016/j.cub.2004.06.017.

Abstract

Post-translational modification with myristoyl or prenyl groups is essential for membrane association of many small GTPases in the Ras superfamily. Two recent papers show that, rather than myristoylation, amino-terminal acetylation of the Arf-like protein Arl3p is required for Golgi targeting via an interaction with an integral membrane protein called Sys1.

Publication types

  • Review

MeSH terms

  • ADP-Ribosylation Factors / metabolism*
  • Acetylation
  • Golgi Apparatus / metabolism*
  • Membrane Proteins / metabolism*
  • Models, Biological*
  • Protein Processing, Post-Translational / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Vesicular Transport Proteins
  • ras Proteins / metabolism*
  • ras Proteins / physiology

Substances

  • Membrane Proteins
  • Saccharomyces cerevisiae Proteins
  • Sys1 protein, S cerevisiae
  • Vesicular Transport Proteins
  • ADP-Ribosylation Factors
  • ARL3 protein, S cerevisiae
  • ras Proteins