Basic biochemistry of cell surface carbohydrates and aspects of the tissue distribution of histo-blood group ABH and related glycosphingolipids

APMIS Suppl. 1992;27:18-27.

Abstract

Cell surface carbohydrates may be protein- or lipid-linked. The structural polymorphism of the oligosaccharide chains is extensive due to variations in monosaccharide composition, carbohydrate sequence, branching, linkage position and linkage anomericity. Blood group ABH and related glycosphingolipids show a remarkable tissue-specific expression with possible implications in areas such as transfusion medicine, transplantation surgery and oncology. This communication gives a condensed description of the present knowledge of the tissue-specific distribution of histo-blood glycolipids in humans.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ABO Blood-Group System / chemistry*
  • ABO Blood-Group System / metabolism
  • Antigens, Surface / chemistry
  • Carbohydrate Sequence
  • Glycosphingolipids / chemistry*
  • Glycosphingolipids / metabolism
  • Humans
  • Lewis Blood Group Antigens / chemistry
  • Lewis Blood Group Antigens / metabolism
  • Membrane Glycoproteins / chemistry
  • Membrane Glycoproteins / metabolism
  • Molecular Sequence Data
  • Tissue Distribution

Substances

  • ABO Blood-Group System
  • Antigens, Surface
  • Glycosphingolipids
  • Lewis Blood Group Antigens
  • Membrane Glycoproteins