Detection of HIV-1 genome in leukocytes of human colostrum from anti-HIV-1 seropositive mothers

AIDS Res Hum Retroviruses. 1992 Jul;8(7):1283-7. doi: 10.1089/aid.1992.8.1283.


In order to obtain more information about the presence of HIV-1 in mononuclear cells of colostrum, research was carried out on both the HIV-1 genome in the cellular fraction of colostrum and the viral antibody in cell-free colostrum of eight anti-HIV-1 seropositive asymptomatic mothers. In five cases cell fractions of the colostrum harbored HIV-1 genome by DNA-DNA and DNA-RNA in situ hybridization, whereas viral antibody were detected in all cell-free colostrum specimens. The data confirms the colostrum as a possible route of HIV-1 infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Colostrum / microbiology*
  • DNA, Viral / analysis
  • Female
  • Genome, Viral
  • HIV Antibodies / analysis
  • HIV Seropositivity / immunology
  • HIV Seropositivity / microbiology*
  • HIV-1 / genetics
  • HIV-1 / isolation & purification*
  • Humans
  • Infant, Newborn
  • Leukocytes / microbiology*
  • Mothers
  • Nucleic Acid Hybridization
  • RNA, Viral / analysis


  • DNA, Viral
  • HIV Antibodies
  • RNA, Viral