Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City

Clin Infect Dis. 2004 Jul 1;39(1):55-60. doi: 10.1086/421495. Epub 2004 Jun 14.


Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing beta -lactamase. In 3 strains, TEM-30, an inhibitor-resistant beta -lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta -lactamase in the United States.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbapenems / metabolism
  • Carbapenems / pharmacology*
  • Drug Resistance, Bacterial
  • Humans
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests
  • New York City
  • beta-Lactam Resistance / physiology*
  • beta-Lactamases / metabolism*


  • Carbapenems
  • beta-lactamase IRT-2
  • beta-lactamase KPC-2
  • beta-Lactamases