Abstract
Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection occurs commonly. The introduction of antiretroviral therapy can result in immune reconstitution hepatitis. We describe 2 coinfected patients who developed clinical flares of HBV disease, despite the inclusion of lamivudine, a drug with anti-HBV activity, in their HAART regimens. Potential strategies to manage individuals with HBV/HIV coinfection are discussed.
MeSH terms
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Adult
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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Antiretroviral Therapy, Highly Active
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CD4 Lymphocyte Count
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Female
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HIV Infections / complications
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HIV Infections / drug therapy
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HIV Infections / immunology*
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Hepatitis B / complications
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Hepatitis B / drug therapy
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Hepatitis B / immunology*
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Hepatitis B virus / immunology*
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Humans
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Immunity / drug effects*
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Lamivudine / pharmacology*
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Lamivudine / therapeutic use
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Middle Aged
Substances
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Anti-HIV Agents
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Lamivudine