Immune reconstitution hepatitis in HIV and hepatitis B coinfection, despite lamivudine therapy as part of HAART

Clin Infect Dis. 2004 Jul 1;39(1):129-32. doi: 10.1086/421386. Epub 2004 Jun 1.

Abstract

Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection occurs commonly. The introduction of antiretroviral therapy can result in immune reconstitution hepatitis. We describe 2 coinfected patients who developed clinical flares of HBV disease, despite the inclusion of lamivudine, a drug with anti-HBV activity, in their HAART regimens. Potential strategies to manage individuals with HBV/HIV coinfection are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-HIV Agents / pharmacology*
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • Hepatitis B / complications
  • Hepatitis B / drug therapy
  • Hepatitis B / immunology*
  • Hepatitis B virus / immunology*
  • Humans
  • Immunity / drug effects*
  • Lamivudine / pharmacology*
  • Lamivudine / therapeutic use
  • Middle Aged

Substances

  • Anti-HIV Agents
  • Lamivudine