Clinical trial experience with Functional Assessment of Cancer Therapy-Lung in conventional and targeted non-small cell lung cancer therapy

Semin Oncol. 2004 Jun;31(3 Suppl 9):16-22. doi: 10.1053/j.seminoncol.2004.04.009.


Advanced non-small cell lung cancer is associated with a low rate of long-term survival and a range of painful and debilitating symptoms. Various self-report questionnaires have been developed to monitor non-small cell lung cancer-related symptoms and quality of life over the course of treatment. The Functional Assessment of Cancer Therapy-Lung questionnaire is a widely used and well-validated lung cancer-specific instrument. It has been used to assess quality of life in numerous lung cancer clinical trials investigating a variety of therapeutic agents, including chemotherapy, radiation therapy, and targeted therapy. The Functional Assessment of Cancer Therapy-Lung is predictive of both tumor response and patient survival, and has been found to be highly sensitive to changes in clinical indicators.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Clinical Trials as Topic*
  • Humans
  • Lung Neoplasms / therapy*
  • Quality of Life*
  • Severity of Illness Index*
  • Sickness Impact Profile*