While general dentists have used many modalities to reduce fear and anxiety in the dental office, including iatrosedation (calming words), distraction techniques, conditioning techniques, and empathy, there still are patients who need pharmacologic management of fear and anxiety to receive dental care. Anxiolysis, the lightest level of sedation, can be employed by all dentists and is safe and effective when used properly. This article presents three cases to introduce the anxiolysis technique as an in-office sedation procedure that can be used by all general dentists.