Successful treatment with succinate in a patient with MELAS

Intern Med. 2004 May;43(5):427-31. doi: 10.2169/internalmedicine.43.427.


We present a case report of a 27-year-old man with MELAS, who presented with general convulsions and left flaccid hemiparesis. Anticonvulsant drugs failed to achieve complete control of his convulsions. A good response to oral administration of succinate has been maintained for more than 30 months, with no recurrence of any stroke-like episode. Succinate therapy may have potential for treatment of uncontrolled convulsive MELAS patients.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Electroencephalography
  • Follow-Up Studies
  • Humans
  • MELAS Syndrome / diagnosis*
  • MELAS Syndrome / drug therapy*
  • Magnetic Resonance Imaging
  • Male
  • Severity of Illness Index
  • Succinic Acid / administration & dosage*
  • Tomography, Emission-Computed
  • Treatment Outcome


  • Succinic Acid