PDGF signaling in cells and mice

Cytokine Growth Factor Rev. 2004 Aug;15(4):205-13. doi: 10.1016/j.cytogfr.2004.03.003.


Since its discovery over three decades ago, platelet-derived growth factor (PDGF) has been a model system for learning how growth factors regulate biological processes. For the first several decades investigators used cells grown in tissue culture. More recently, PDGF signaling has also been investigated in mice. This review outlines the advances in these two systems, and highlights some of the directions for future investigation.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Growth Substances / metabolism
  • Mice
  • Phenotype
  • Platelet-Derived Growth Factor / physiology*
  • Protein Structure, Tertiary
  • Receptor, Platelet-Derived Growth Factor alpha / metabolism
  • Retina / metabolism
  • Signal Transduction*
  • Time Factors


  • Growth Substances
  • Platelet-Derived Growth Factor
  • Receptor, Platelet-Derived Growth Factor alpha