Foxp3: A Critical Regulator of the Development and Function of Regulatory T Cells

Shohei Hori; Shimon Sakaguchi

doi:10.1016/j.micinf.2004.02.020

Foxp3: A Critical Regulator of the Development and Function of Regulatory T Cells

Microbes Infect. 2004 Jul;6(8):745-51. doi: 10.1016/j.micinf.2004.02.020.

Authors

Shohei Hori¹, Shimon Sakaguchi

Affiliation

¹ Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. shohei@rcai.riken.jp

PMID: 15207821
DOI: 10.1016/j.micinf.2004.02.020

Abstract

Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autoimmune Diseases
CD4-Positive T-Lymphocytes / immunology
CD4-Positive T-Lymphocytes / physiology
DNA-Binding Proteins / genetics
DNA-Binding Proteins / physiology*
Down-Regulation
Forkhead Transcription Factors
Humans
Hypersensitivity
Immune Tolerance*
Mice
T-Lymphocytes / immunology*
T-Lymphocytes / physiology*

Substances

DNA-Binding Proteins
FOXP3 protein, human
Forkhead Transcription Factors
Foxp3 protein, mouse