Abstract
Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmune Diseases
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / physiology
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology*
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Down-Regulation
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Forkhead Transcription Factors
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Humans
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Hypersensitivity
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Immune Tolerance*
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Mice
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T-Lymphocytes / immunology*
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T-Lymphocytes / physiology*
Substances
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DNA-Binding Proteins
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FOXP3 protein, human
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Forkhead Transcription Factors
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Foxp3 protein, mouse