Foxp3: A Critical Regulator of the Development and Function of Regulatory T Cells

Microbes Infect. 2004 Jul;6(8):745-51. doi: 10.1016/j.micinf.2004.02.020.

Abstract

Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / physiology
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Down-Regulation
  • Forkhead Transcription Factors
  • Humans
  • Hypersensitivity
  • Immune Tolerance*
  • Mice
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / physiology*

Substances

  • DNA-Binding Proteins
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Foxp3 protein, mouse