Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins

Semin Cell Dev Biol. 2004 Apr;15(2):221-9. doi: 10.1016/j.semcdb.2003.12.003.


The expression of the ubiquitin related protein Nedd8/RUB is essential for growth in most organisms. Nedd8/RUB has been shown to modify the cullin subunit of culling-based ubiquitin protein ligases (E3). Neddylation acts to regulate the function of these E3s and organisms with lesions in the neddylation process exhibit severe growth defects. In this review we describe the proteins that participate in neddylation and discuss a model for Nedd8/RUB regulation of ubiquitin ligase function.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cullin Proteins / metabolism*
  • Humans
  • NEDD8 Protein
  • Protein Processing, Post-Translational*
  • Ubiquitins / chemistry
  • Ubiquitins / metabolism*


  • Cullin Proteins
  • NEDD8 Protein
  • NEDD8 protein, human
  • Ubiquitins