Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population

Int J Geriatr Psychiatry. 2004 Jun;19(6):509-15. doi: 10.1002/gps.1077.


The management of dementia in Alzheimer's disease has dramatically changed since the development of anti-dementia drugs. However, there is limited information available regarding the bio-medical aspects of the differing drugs; particularly relating to adults with intellectual disability. Indeed the information available for the intellectual disabled population is limited to adults with Down syndrome. This review highlights the important pharmacological and clinical aspects of donepezil, rivastigmine, galantamine and memantine and supports the view that such drugs play an important part in the management of dementia in adults with intellectual disability. Future clinical and research issues are discussed.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Carbamates / therapeutic use
  • Cholinesterase Inhibitors / therapeutic use*
  • Donepezil
  • Down Syndrome / complications*
  • Galantamine / therapeutic use
  • Humans
  • Indans / therapeutic use
  • Memantine / therapeutic use
  • Nootropic Agents / therapeutic use*
  • Phenylcarbamates*
  • Piperidines / therapeutic use
  • Rivastigmine


  • Carbamates
  • Cholinesterase Inhibitors
  • Indans
  • Nootropic Agents
  • Phenylcarbamates
  • Piperidines
  • Galantamine
  • Donepezil
  • Rivastigmine
  • Memantine