Two karyotypically unrelated clones with the t(5;17) and deletion of 5q in myelodysplastic syndrome

Cancer Genet Cytogenet. 1992 Aug;62(1):100-2. doi: 10.1016/0165-4608(92)90049-e.


We report a patient with primary myelodysplastic syndrome (MDS) and two coexisting karyotypically independent clones. Cytogenetic investigation of bone marrow (BM) cells at diagnosis showed, besides the cells with normal karyotype, a clone that manifests an interstitial deletion of the long arm of chromosome 5 and a second one with a t(5;17). The rarity of finding a BM mosaicism in myelodysplasia with 5q- in some cells and different chromosomal abnormalities in others may be considered to support the multistep theory of pathogenesis in MDS.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 17*
  • Chromosomes, Human, Pair 5*
  • Female
  • Humans
  • Karyotyping
  • Myelodysplastic Syndromes / genetics*
  • Myelodysplastic Syndromes / therapy
  • Translocation, Genetic / genetics*