A study of the state of solvation of the adenine ring in adenosine and adenosine 5'-monophosphate disodium salt in water and in a (7.5:2.5) water-TFE mixture has been carried out by measurement of homo- and heteronuclear intermolecular NOE enhancements between water or TFE and the aromatic protons of these compounds. The results give evidence of site specificity in solute-solvent interaction for both solvent systems and preferential solvation of the solute by TFE in the water-TFE mixture. Significant pH dependence of these interactions has been discovered.