Pigmentation of the gums following hydroxychloroquine therapy

Cutis. 1992 Apr;49(4):281-2.


The authors describe a case of pigmentation of the gums occurring after therapy with hydroxychloroquine. A twenty-eight-year-old woman with discoid lupus erythematosus was treated only with hydroxychloroquine. After seven months of this therapy, a diffuse bluish-gray pigmentation was apparent on the vestibular surface of the gums of both dental arches. No pigmented lesions were noticed on either the skin or the nails.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Gingival Diseases / chemically induced*
  • Humans
  • Hydroxychloroquine / adverse effects*
  • Hydroxychloroquine / therapeutic use
  • Lupus Erythematosus, Discoid / drug therapy
  • Pigmentation Disorders / chemically induced*


  • Hydroxychloroquine