Determinants of quaternary association in legume lectins

Protein Sci. 2004 Jul;13(7):1735-49. doi: 10.1110/ps.04651004.


It is well known that the sequence of amino acids in proteins code for its tertiary structure. It is also known that there exists a relationship between sequence and the quaternary structure of proteins. The question addressed here is whether the nature of quaternary association can be predicted from the sequence, similar to the three-dimensional structure prediction from the sequence. The class of proteins called legume lectins is an interesting model system to investigate this problem, because they have very high sequence and tertiary structure homology, with diverse forms of quaternary association. Hence, we have used legume lectins as a probe in this paper to (1) gain novel insights about the relationship between sequence and quaternary structure; (2) identify the sequence motifs that are characteristic of a given type of quaternary association; and (3) predict the quaternary association from the sequence motif.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Amino Acid Sequence
  • Computational Biology
  • Computer Simulation*
  • Lectins / chemistry*
  • Molecular Sequence Data
  • Plant Proteins / chemistry
  • Plants / chemistry*
  • Protein Structure, Quaternary*
  • Sequence Alignment
  • Software*
  • Structural Homology, Protein*


  • Lectins
  • Plant Proteins

Associated data

  • GENBANK/AA062538
  • SWISSPROT/P02874
  • SWISSPROT/P16030
  • SWISSPROT/P19664
  • SWISSPROT/P29257
  • SWISSPROT/P81371