Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults

J Infect Dis. 2004 Jul 15;190(2):373-8. doi: 10.1086/421524. Epub 2004 Jun 18.


Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV)-infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large. Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Viral / analysis*
  • Antibodies, Viral / blood
  • Antigens, Viral / immunology
  • Female
  • Humans
  • Immunity, Mucosal
  • Immunoglobulin A / analysis
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Nasal Mucosa / immunology
  • Neutralization Tests
  • Respiratory Syncytial Virus Infections / immunology*
  • Respiratory Syncytial Viruses / immunology*
  • Risk Factors
  • Viral Proteins / immunology


  • Antibodies, Viral
  • Antigens, Viral
  • Immunoglobulin A
  • Immunoglobulin G
  • Viral Proteins