Evaluation of Astroglide, a new vaginal lubricant: effects of length of exposure and concentration on sperm motility

Fertil Steril. 1992 Sep;58(3):630-2.


Traditional vaginal lubricants have been shown to adversely affect sperm motility. Astroglide, a new vaginal lubricant, and K-Y Jelly were tested at varying concentrations to assess their suitability for infertility patients requiring a lubricant. The vaginal lubricants tested impaired sperm motility in a concentration-dependent but not time-dependent manner. We conclude that all traditional vaginal lubricants should be avoided in patients desiring conception. Future studies should attempt to mimic in vivo conditions and focus on concentration-dependent effects.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cellulose / analogs & derivatives
  • Cellulose / pharmacology
  • Female
  • Glycerol / pharmacology*
  • Humans
  • Male
  • Phosphates / pharmacology
  • Propylene Glycols / pharmacology
  • Solubility
  • Sperm Motility / drug effects*
  • Time Factors
  • Vagina / physiology*
  • Vaginal Creams, Foams, and Jellies / pharmacology*
  • Water


  • Astroglide
  • K-Y jelly
  • Phosphates
  • Propylene Glycols
  • Vaginal Creams, Foams, and Jellies
  • Water
  • Cellulose
  • Glycerol