Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032

J Antibiot (Tokyo). 2004 Apr;57(4):271-9. doi: 10.7164/antibiotics.57.271.


A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Aminobenzoic Acid / antagonists & inhibitors*
  • 4-Aminobenzoic Acid / metabolism
  • Actinobacteria / chemistry
  • Actinobacteria / metabolism*
  • Amino Acids, Aromatic / antagonists & inhibitors
  • Amino Acids, Aromatic / metabolism
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Geologic Sediments / microbiology
  • Macrolides / isolation & purification*
  • Macrolides / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Phylogeny


  • Amino Acids, Aromatic
  • Anti-Bacterial Agents
  • Macrolides
  • 4-Aminobenzoic Acid