E pluribus unum, ex uno plura: quantitative and single-gene perspectives on the study of behavior

Annu Rev Neurosci. 2004;27:79-105. doi: 10.1146/annurev.neuro.27.070203.144323.


Genetic studies of behavior have traditionally come in two flavors: quantitative genetic studies of natural variants and single-gene studies of induced mutants. Each employed different techniques and methods of analysis toward the common, ultimate goal of understanding how genes influence behavior. With the advent of new genomic technologies, and also the realization that mechanisms underlying behavior involve a considerable degree of complex gene interaction, the traditionally separate strands of behavior genetics are merging into a single, synthetic strategy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior / physiology*
  • Drosophila / genetics
  • Genes / genetics*
  • Genetics, Behavioral / methods
  • Genetics, Behavioral / trends*
  • Genome*
  • Humans
  • Mice / genetics
  • Models, Animal
  • Mutation / genetics