The Nogo signaling pathway for regeneration block

Annu Rev Neurosci. 2004;27:341-68. doi: 10.1146/annurev.neuro.27.070203.144340.


A hostile environment and decreased regenerative capacity may contribute to the failure of axon regeneration in the adult central nervous system. Recent studies leading to the identification of several myelin-associated inhibitors and their signaling molecules provide opportunitities to assess the contribution of these inhibitory molecules in restricting axon regeneration. These findings may ultimately allow for the development of strategies to alleviate the inhibitory effects of such molecules in an effort to encourage axon regeneration after spinal cord and brain injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain Injuries / metabolism
  • Brain Injuries / physiopathology
  • Brain Injuries / therapy
  • Central Nervous System / cytology
  • Central Nervous System / growth & development*
  • Central Nervous System / metabolism*
  • Growth Cones / metabolism*
  • Growth Cones / ultrastructure
  • Growth Inhibitors / metabolism*
  • Humans
  • Myelin Proteins / metabolism*
  • Nerve Regeneration / physiology*
  • Nogo Proteins
  • Receptors, Cell Surface / metabolism
  • Signal Transduction / physiology


  • Growth Inhibitors
  • Myelin Proteins
  • Nogo Proteins
  • RTN4 protein, human
  • Receptors, Cell Surface