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Review
. 2004 Jun;10 Suppl 1:S58-61.
doi: 10.1191/1352458504ms1032oa.

Mitoxantrone as a Potential Therapy for Primary Progressive Multiple Sclerosis

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Review

Mitoxantrone as a Potential Therapy for Primary Progressive Multiple Sclerosis

Olaf Stüve et al. Mult Scler. .

Abstract

Mitoxantrone (Novantrone) was the first drug approved in western Europe and North America for treatment of secondary progressive multiple sclerosis (SPMS) and progressive relapsing MS (PRMS). Pharmacological properties of mitoxantrone, its role in SPMS, the study rational and design of an ongoing multi-centre, double blind, randomized, placebo-controlled phase 2 trial will be outlined in this article.

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