Interleukin-6 (IL-6) in adjuvant arthritis of rats and its pharmacological modulation

Int J Immunopharmacol. 1992 May;14(4):565-71. doi: 10.1016/0192-0561(92)90117-4.


The levels of serum interleukin-6 (IL-6) were measured during the course of adjuvant arthritis (FAA) in male Lewis rats. In the course of the disease serum IL-6 levels increase with a clear correlation with morphologic disease signs. Additionally, the FAA-inducing antigen, heat-killed Mycobacterium tuberculosis, was found to be a strong inducer of IL-6 production by spleen cells in vitro. The effects of the anti-rheumatic drugs indometacin, dexamethasone, cyclophosphamide and cyclosporin A (CsA) on IL-6 levels during FAA were determined. Complete normalization of serum IL-6 levels was observed with dexamethasone, cyclophosphamide and CsA whereas indometacin only partly reduced serum IL-6 levels.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Arthritis, Experimental / immunology*
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Interleukin-6 / blood*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Spleen / cytology
  • Spleen / immunology


  • Anti-Inflammatory Agents
  • Interleukin-6