Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders

Trends Neurosci. 2004 Jul;27(7):400-6. doi: 10.1016/j.tins.2004.05.008.


Neurodevelopmental disorders typically have complex endophenotypes, which can include abnormalities in neuronal excitability, processing of complex information, as well as behaviors such as anxiety and social interactions. Converging experimental and clinical evidence suggests that altered interneuron development may underlie part of the pathophysiological process of such disorders. Consistent with this, mice with abnormal hepatocyte growth factor signaling exhibit disturbances in the development of specific interneuron subclasses that are paralleled by seizure activity and a complex behavioral phenotype. Mutations in molecules that regulate different aspects of interneuron development could provide the heterogeneity in genetic susceptibility that, when combined with environmental disturbances, results in a phenotypic spectrum that serves as the hallmark pathophysiology for autism, mental retardation, schizophrenia and other neurodevelopmental disorders.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain Diseases / pathology*
  • Brain Diseases / physiopathology
  • Child
  • Developmental Disabilities / pathology*
  • Developmental Disabilities / physiopathology
  • Humans
  • Interneurons / pathology*
  • Neocortex / abnormalities*
  • Neocortex / pathology*