B cell antigen receptor signaling 101

Mol Immunol. 2004 Jul;41(6-7):599-613. doi: 10.1016/j.molimm.2004.04.008.


All cells continually survey their environment and make decisions based on cues encountered. This requires specific receptors that detect such cues, then transduce signals that initiate the appropriate responses. B lymphocytes provide an archetypal model for such 'adaptive' cellular responses, where signals transmitted by the B cell Ag-receptor (BCR) influence not only cellular selection, maturation, and survival, but are imperative in generating the ultimate effector function of B cells, i.e. antibody production. While other extracellular stimuli and their cognate receptor signals can also influence B cell development, BCR-mediated signals and the way in which they are integrated and regulated are paramount in defining the cell's physiological fate.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • B-Lymphocytes / physiology*
  • Humans
  • Receptors, Antigen, B-Cell / immunology
  • Receptors, Antigen, B-Cell / physiology*
  • Signal Transduction / immunology
  • Signal Transduction / physiology*


  • Receptors, Antigen, B-Cell