The Notch and Sonic hedgehog signalling pathways in immunity

Mol Immunol. 2004 Jul;41(6-7):715-25. doi: 10.1016/j.molimm.2004.04.017.

Abstract

There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / physiology
  • Cell Differentiation / immunology
  • Cell Differentiation / physiology
  • Hedgehog Proteins
  • Humans
  • Immune System / immunology
  • Immune System / physiology*
  • Membrane Proteins / immunology
  • Membrane Proteins / physiology*
  • Neoplasms / immunology
  • Pneumonia / immunology
  • Receptors, Notch
  • Signal Transduction / immunology
  • Signal Transduction / physiology*
  • Trans-Activators / immunology
  • Trans-Activators / physiology*

Substances

  • Hedgehog Proteins
  • Membrane Proteins
  • Receptors, Notch
  • SHH protein, human
  • Trans-Activators