Gadolinium-based contrast media may be nephrotoxic even at approved doses

Eur Radiol. 2004 Sep;14(9):1654-6. doi: 10.1007/s00330-004-2379-0. Epub 2004 Jun 22.


It is generally believed that gadolinium-based contrast media are not nephrotoxic at the approved doses for MR (<0.3 mmol/kg body weight). Recently, a patient with diabetic nephropathy required dialysis because of anuria 6-7 days after MR angiography with 0.14 mmol/kg body weight gadolinium-DTPA-BMA to assess renal artery stenosis. No special precautions (e.g., hydration) had been taken. The serum creatinine levels had been within 200 and 300 micromol/l for the last 3 years with a very slow increase. This case highlights that gadolinium-based contrast media can cause contrast medium-induced nephropathy even at doses below 0.2 mmol/kg body weight in patients with multiple risk factors.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Contrast Media / toxicity*
  • Diabetic Nephropathies / diagnosis
  • Diagnosis, Differential
  • Dose-Response Relationship, Drug
  • Gadolinium / toxicity*
  • Gadolinium DTPA / toxicity*
  • Humans
  • Kidney Function Tests*
  • Magnetic Resonance Angiography*
  • Male
  • Renal Artery Obstruction / diagnosis*
  • Renal Insufficiency / chemically induced*
  • Renal Insufficiency / diagnosis


  • Contrast Media
  • gadodiamide
  • Gadolinium
  • Gadolinium DTPA