Thrombophilic polymorphisms in preterm delivery

Blood Cells Mol Dis. 2004 Jul-Aug;33(1):51-6. doi: 10.1016/j.bcmd.2004.04.011.


Single nucleotide polymorphisms tumor necrosis factor (TNF) G-308A, coagulation factors V G1691A and II G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T, as well as the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism were investigated in 86 women with a history of premature delivery (PD) and compared with those of a control group of adults from Guadalajara, Mexico (a minimum of 162 individuals were typed for each polymorphism). Significant differences in the frequency of these polymorphisms were found for MTHFR C677T (increased), and the ACE deletion (increased) among women who had a history of preterm delivery compared with controls. These polymorphisms therefore might be associated with PD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Factor V / genetics
  • Female
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Mexico
  • Peptidyl-Dipeptidase A / genetics
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide
  • Pregnancy
  • Pregnancy Complications, Hematologic / blood
  • Pregnancy Complications, Hematologic / epidemiology
  • Premature Birth / epidemiology
  • Premature Birth / genetics*
  • Prothrombin / genetics
  • Sequence Deletion
  • Thrombophilia / complications
  • Thrombophilia / epidemiology
  • Thrombophilia / genetics*
  • Tumor Necrosis Factor-alpha / genetics


  • Tumor Necrosis Factor-alpha
  • Factor V
  • Prothrombin
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Peptidyl-Dipeptidase A