Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration

J Neuroimmunol. 2004 Jul;152(1-2):121-5. doi: 10.1016/j.jneuroim.2004.01.024.


Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its soluble receptor components (sIL-6R and sGp130) in CSF and serum from control subjects and patients after different types of seizures. IL-6 levels were increased after seizures, whereas sIL-6R levels were decreased. Interestingly, the levels of IL-6 were strongly increased after recurrent generalized tonic-clonic seizures (GTCS), whereas after single tonic-clonic or prolonged partial seizures IL-6 levels were increased to lesser extent. These results provide further support for a hypothesis of cytokine production induced by seizure activity per se.

Publication types

  • Comparative Study

MeSH terms

  • Antigens, CD / blood
  • Antigens, CD / cerebrospinal fluid
  • Cytokine Receptor gp130
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Interleukin-6 / blood*
  • Interleukin-6 / cerebrospinal fluid*
  • Membrane Glycoproteins / blood
  • Membrane Glycoproteins / cerebrospinal fluid
  • Receptors, Interleukin-6 / analysis
  • Seizures / immunology*
  • Seizures / physiopathology*


  • Antigens, CD
  • IL6ST protein, human
  • Interleukin-6
  • Membrane Glycoproteins
  • Receptors, Interleukin-6
  • Cytokine Receptor gp130