Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Jun;16 Suppl 1:S38-9.
doi: 10.1038/sj.ijir.3901214.

Growth Factor Therapy and Neuronal Nitric Oxide Synthase

Affiliations
Review

Growth Factor Therapy and Neuronal Nitric Oxide Synthase

C-S Lin et al. Int J Impot Res. .

Abstract

Trauma to the cavernous nerve is a known cause of erectile dysfunction, with lengthy and often incomplete recovery. Using rat models, we have previously shown that injury to the cavernous nerves or ligation of pudendal arteries causes a significant decrease of neuronal nitric oxide synthase (nNOS) in the dorsal nerve of the penis and intracavernosal tissue as well as loss of erectile response to neurostimulation. Intracavernous injection of vascular endothelial growth factor or brain-derived neurotrophic factor facilitates the recovery of nNOS and erectile function. Studies are underway to elucidate the molecular mechanism of cavernous nerve regeneration and the potential of using growth factors to enhance the recovery of erectile function in patients after radical pelvic surgery. International Journal of Impotence Research (2004) 16, S38-S39. doi:10.1038/sj.ijir.3901214

Similar articles

See all similar articles

Cited by 7 articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback