Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):449-52. doi: 10.1016/j.jsbmb.2004.03.014.


Treatment from weaning until old age with 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) prevents diabetes in NOD mice. It is mainly through its actions on dendritic cells (DCs), that 1,25(OH)(2)D(3) changes the function of potentially autoreactive T lymphocytes. In contrast, early life treatment (from 3 to 70 days of age) of NOD mice with vitamin D or 1,25(OH)(2)D(3) did not influence final diabetes incidence at 200 days of age. Also in spontaneous diabetic BB rats, diabetes could not be prevented by early life treatment (from 3 to 50 days of age) with vitamin D (1000 IU per day) or 1,25(OH)(2)D(3) (0.2 microg/kg per day or 1 microg/kg per 2 days). However, when NOD mice were made vitamin D deficient in early life (until 100 days of age), diabetes onset occurred earlier and final incidence was increased. These data further support a role for vitamin D and its metabolites in the pathogenesis of type 1 diabetes in NOD mice.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcitriol / pharmacology*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / prevention & control*
  • Mice
  • Mice, Inbred NOD
  • T-Lymphocytes / immunology
  • Vitamin D / pharmacology*


  • Vitamin D
  • Calcitriol