Clinical manifestations and early diagnosis of Sjögren syndrome

Arch Intern Med. 2004 Jun 28;164(12):1275-84. doi: 10.1001/archinte.164.12.1275.


Sjögren syndrome (SS) is a common autoimmune disease evidenced by broad organ-specific and systemic manifestations, the most prevalent being diminished lacrimal and salivary gland function, xerostomia, keratoconjunctivitis sicca, and parotid gland enlargement. Primary SS presents alone, and secondary SS occurs in connection with autoimmune rheumatic diseases. In addition, symptoms do not always present concurrently. This diversity of symptomatic expression adds to the difficulty in initial diagnosis. Armed with the recently refined criteria for diagnosis, specialists, such as rheumatologists, primary care physicians, ophthalmologists, and dentists, who would otherwise focus only on those symptoms that encompass their areas of expertise, can get a comprehensive image of the presenting patient, leading to earlier identification and treatment of SS.

Publication types

  • Review

MeSH terms

  • Humans
  • Sjogren's Syndrome / diagnosis*
  • Sjogren's Syndrome / physiopathology*
  • Sjogren's Syndrome / therapy
  • Time Factors