Hysterectomy and bilateral oophorectomy for severe premenstrual syndrome

Hum Reprod. 2004 Sep;19(9):2152-5. doi: 10.1093/humrep/deh354. Epub 2004 Jun 30.


Background: Premenstrual syndrome (PMS) is a chronic, poorly understood psycho-endocrine disorder severely affecting 5%; of women. Hormonal therapy which suppresses ovulation is the mainstay of medical treatment, but these interventions are rarely permanent. We evaluated the effectiveness and patient satisfaction with total abdominal hysterectomy/bilateral salpingo-oophorectomy (TAH/BSO) in PMS sufferers, and assessed the post-operative HRT continuation.

Methods: All women undergoing TAH/BSO for severe PMS between January 1994 and April 2000 were interviewed and responses recorded by structured questionnaire.

Results: Forty-seven women were interviewed. Median age was 42 years (interquartile range 39.8-46.6) at the time of surgery. They had suffered with PMS for a mean of 9.68 years (SD 6.8) and received treatment for a mean of 3.57 years (SD 2.0) prior to referral to a gynaecologist. Fifty-two percent were treated with estradiol patches and 48% with estradiol implants prior to TAH/BSO. Ninety-six percent of women were 'satisfied' or 'very satisfied' with TAH/BSO, and 93.6% declared complete resolution of their cyclical symptoms; 93.6% were continuing with HRT usually by implants of estradiol and testosterone for a mean duration of 3.8 years (SD 1.86) post-operatively.

Conclusion: Despite few reports of TAH/BSO as a treatment for severe PMS, we have found surgery, coupled with appropriate HRT, to be an extremely effective and well-accepted permanent cure for PMS.

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Drug Implants
  • Estradiol / administration & dosage
  • Estradiol / therapeutic use
  • Female
  • Humans
  • Hysterectomy*
  • Interviews as Topic
  • Middle Aged
  • Ovariectomy*
  • Patient Satisfaction
  • Postoperative Care
  • Premenstrual Syndrome / physiopathology*
  • Premenstrual Syndrome / surgery*
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Testosterone / administration & dosage
  • Testosterone / therapeutic use
  • Treatment Outcome


  • Drug Implants
  • Testosterone
  • Estradiol