p27 and Barrett's esophagus: a review*

Dis Esophagus. 2004;17(2):113-7. doi: 10.1111/j.1442-2050.2004.00402.x.

Abstract

The rising prevalence of Barrett's esophagus and Barrett's associated adenocarcinoma in the Western world has stimulated increasing interest in this disease. This has resulted in a plethora of articles concerning its molecular biology, but the tumor suppressor gene, p27, has received little attention. In this article, we review the literature concerning the role of p27 in Barrett's esophagus and its malignant transformation, and we evaluate its possible role as an important clinical biomarker, as well as potential chemopreventive clinical agents aimed at substituting its antitumoral activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy
  • Animals
  • Barrett Esophagus / genetics*
  • Barrett Esophagus / pathology
  • Barrett Esophagus / therapy
  • Biomarkers, Tumor
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / physiology
  • Cell Transformation, Neoplastic / genetics
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclooxygenase 2
  • Disease Models, Animal
  • Esophageal Neoplasms / genetics*
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / therapy
  • Esophagus / enzymology
  • Esophagus / pathology
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Membrane Proteins
  • Mice
  • Mucous Membrane / pathology
  • Mutation
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Rats
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / physiology

Substances

  • Biomarkers, Tumor
  • Cdkn1b protein, mouse
  • Cdkn1b protein, rat
  • Cell Cycle Proteins
  • Membrane Proteins
  • Tumor Suppressor Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases